4 edition of Pulmonary Surfactant Metabolism found in the catalog.
Pulmonary Surfactant Metabolism
H. P. Haagsman
February 1995 by R G Landes Co .
Written in English
Medical Intelligence Unit
|The Physical Object|
|Number of Pages||118|
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Lipid Metabolism and Pulmonary Surfactant Overview The lung plays an important series of functions in connection with lipids such as de novo synthesis of fatty acids and oxidation, lipid esterification, acid-ester bonds hydrolysis, hydrolysis of lipoproteins, synthesis of phosphatidylcholine, synthesis and secretion of prostaglandins and other Cited by: 5.
Pulmonary surfactant is a surface-active lipoprotein complex (phospholipoprotein) formed by type II alveolar proteins and lipids that make up the surfactant have both hydrophilic and hydrophobic regions.
By adsorbing to the air-water interface of alveoli, with hydrophilic head groups in the water and the hydrophobic tails facing towards the air, the main lipid component of surfactant. Overview of surfactant composition and metabolism. Pulmonary surfactant is a complex mixture of phospholipids, neutral lipids, and specific proteins; it is produced by the alveolar type II epithelial cell (AEC2), stored in intracellular organelles known as lamellar bodies, and secreted by exocytosis into the alveolar lumen.
The major lipid. tion [20–26]. In humans, impairment of lipid metabolism in pulmonary T2C causes surfactant insufficiency result-ing in deficient pulmonary function.
For example, ABCA3 loss of function results in neonatal respiratory distress syndrome and defective lamellar body synthesis . In the alveolar lumen, surfactant reduces the surfaceCited by: Pulmonary surfactant is used as a medication to treat and prevent respiratory distress syndrome in newborn babies.
Prevention is generally done in babies born at a gestational age of less than 32 weeks. It is given by the endotracheal tube.
Onset of effects is rapid. A number of doses may be : Monograph. Although modest pulmonary responses to empiric medical therapies including corticosteroids, azithromycin, hydroxychloroquine, and prolonged mechanical ventilation have been observed in a subset of patients with genetic disorders of surfactant metabolism, (17–22) many affected infants and children progress to lung transplantation.
Pathophysiology. As discussed previously, surfactant is Pulmonary Surfactant Metabolism book to prevent the collapse of alveoli and distal airways. Any process Pulmonary Surfactant Metabolism book interferes with the production, function, or metabolism of surfactant can have disastrous consequences on pulmonary function.
Introduction. Pulmonary surfactant, a complex of lipids and proteins lining the alveolar surface, is responsible for lowering surface tension at the air-liquid interface thereby preventing alveolar collapse at the end of expiration [1, 2].However, lung surfactant is also an integral component of the lung's innate immune system helping to control inflammation and to prevent microbial infections.
Pulmonary alveolar proteinosis (PAP) is a syndrome characterized by the accumulation of alveolar surfactant and dysfunction of alveolar macrophages. PAP results in progressive dyspnoea of. The Pulmonary Surfactant. Within the lung, an aqueous lining layer exists to varying degrees within the alveoli and intrapulmonary duct system .The composition and characteristics of this layer Pulmonary Surfactant Metabolism book critical to many lung functions, for example gas exchange, defense against microorganisms and pulmonary compliance.
1. Introduction. Pulmonary surfactant is an essential lipid–protein complex that lines and stabilizes the alveolar respiratory interface, allowing for gas exchange during the breathing cycle (Clements,Avery and Mead, ).Besides its physical function, which is achieved through a dramatic surface tension reduction at the air–water interface, surfactant constitutes the first line of.
In the bronchoalveolar space this critical balance is maintained by innate immune proteins, termed surfactant proteins. Among these, surfactant protein D (SP-D) plays a central role in the pulmonary host defence and the modulation of allergic responses. Several human lung diseases are characterized by decreased levels of bronchoalveolar SP-D.
Surfactant metabolism dysfunction is a condition where pulmonary surfactant is insufficient for adequate respiration.
Surface tension at the liquid-air interphase in the alveoli makes the air sacs prone to collapsing post expiration. This is due to the fact that water molecules in the liquid-air surface of alveoli are more attracted to one another than they are to molecules in the air.
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Haagsman. The alveolar region of the lung creates an extensive epithelial surface that mediates the transfer of oxygen and carbon dioxide required for respiration after birth. Maintenance of pulmonary function depends on the function of type II epithelial cells that synthesize and secrete pulmonary surfactant.
In 93 preterm infants ≤32 weeks of gestational age and 12 control infants, epithelial lining fluid disaturated-phosphatidylcholine, surfactant protein A and B, albumin, and myeloperoxidase activity were assessed after intubation and before exogenous surfactant administration.
We found that disaturat. The pulmonary surfactant is produced by the alveolar type-II (AT-II) cells of the lungs. It is essential for efficient exchange of gases and for maintaining the structural integrity of alveoli. Surfactant is a secretory product, composed of lipids and proteins.
Phosphatidylcholine and phosphatidylglycerol are the major lipid constituents and SP. Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and secreted into the airspaces, where it coats and protects the large respiratory air–liquid interface.
Surfactant, assembled as a complex network of membranous structures, integrates elements in charge of reducing surface tension to a minimum along the breathing cycle, thus maintaining a large surface. Pulmonary surfactant -- Congresses. Respiratory distress syndrome -- Congresses. Pulmonary surfactant.
Respiratory distress syndrome. Lung Diseases -- etiology. Lung Diseases -- therapy. Pulmonary Surfactants -- metabolism. Pulmonary Surfactants -- therapeutic use.
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This book represents a comprehensive update on pulmonary surfactant by merging classical knowledge with new information.
Topics include surfactant secretion and alveolar processing and recycling; physical bases and different theoretical models of the physiological mechanism for pulmonary surfactant action; recent findings on surfactant-like material in other organs; developmental.
It has been recognized for almost 50 years that a deficiency in surfactant production due to pulmonary immaturity is the principal cause of the respiratory distress syndrome (RDS) observed in prematurely born infants.
1 Secondary surfactant deficiency due to injury to the cells involved in its production and functional inactivation of. Three and a half days after injection, preterm lambs were delivered, and lung function was studied during min ventilation, followed by pulmonary surfactant components analyses.
Pregnant A/J mice were given 30 or mg of leptin or vehicle by intraperitoneal injection according to five study protocols with different doses, number of. Infants with inherited deficiency of pulmonary surfactant protein (SP) B develop respiratory failure at birth and die without lung transplantation.
We examined aspects of surfactant metabolism in lung tissue and lavage fluid acquired at transplantation or postmortem from ten infants born at term with inherited deficiency of SP-B; comparison groups were infants with other forms of chronic lung.
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. Abstract. Pulmonary surfactant reduces surface tension in the lungs to impressive low values. When secreted by the type II cells into the thin liquid layer that lines the alveolar air spaces, vesicles of pulmonary surfactant absorb readily to the air water interface and form an interfacial film.
Since the first edition of this book was published inthere has been a spectacular development in both basic research on the pulmonary surfactant system and the clinical use of surfactant for treatment of lung diseases hence the addition of the subtitle indicating the expansion of knowledge in the field and the expanded information.
An overview of pulmonary surfactant in the neonate: genetics, metabolism, and the role of surfactant in health and disease. Mol Genet Metab.
Jun;97(2) doi: / Epub Feb 4. Pulmonary alveolar proteinosis (PAP) comprises a heterogenous group of diseases characterized by abnormal surfactant accumulation resulting in respiratory insufficiency, and defects in alveolar macrophage- and neutrophil-mediated host defense.
Basic. Jobe A () Metabolism of endogenous surfactant and exogenous surfactant for replacement therapy. Semin Perinatol – PubMed Google Scholar Jobe A, Ikegami M () Movement of fluid and particles between the airspaces and pulmonary interstitium protein permeability abnormalities in the preterm.
ABCG1 regulates pulmonary surfactant metabolism in mice and men Article (PDF Available) in Journal of Lipid Research 58(5):jlr.M March with 71 Reads How we measure 'reads'.
Book: All Authors / Contributors: Philip M Farrell; J J Batenburg. Find more information about: ISBN: OCLC Number: Description: 2 volumes: illustrations ; 24 cm # Pulmonary surfactant--Metabolism.
SPB(Pulmonary Surfactant Associated Protein B)|SFTPB|SP-B|SFTP3|Pulmonary surfactant-associated proteolipid SPL(Phe)|18 kDa pulmonary-surfactant protein|6 kDa protein ELISA Kit Reactivity Human Range ng/ml Sensitivity ng/ml. We examined aspects of surfactant metabolism in lung tissue and lavage fluid acquired at transplantation or postmortem from ten infants born at term with inherited deficiency of SP-B; comparison groups were infants with other forms of chronic lung disease (CLD) and normal infants.
Disease - Pulmonary surfactant metabolism dysfunction 5))) Map to. UniProtKB (1) Reviewed (1) Swiss-Prot. Format. Definition. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant.
Natural pulmonary surfactant contains a mixture of roughly 90% phospholipids (e.g., phosphatidylcholine and phosphatidylglycerol) and 10% associated surfactant proteins (i.e., SP-A, SP-B, SP-C and SP-D).
Curosurf(R) consists of about 99% phospholipids and 1% surfactant associated proteins (SP-B and SP-C only). The essential role of lung surfactant in breathing and therefore in life, is highlighted by surfactant deficiency in premature neonates, which causes neonatal respiratory distress syndrome and results in early death after birth.
In addition, defects in surfactant metabolism. Surfactant is an agent that decreases the surface tension between two media. The surface tension between gaseous-aqueous interphase in the lungs is decreased by the presence of a thin layer of fluid known as pulmonary surfactant.
The pulmonary surfactant is produced by the alveolar type-II (AT-II) cells of the lungs. Pulmonary surfactant is a complex mixture of lipids and specific surfactant-associated proteins lining the epithelial surface of lungs.
Within the alveoli, its main function is to reduce surface tension at the air–liquid interface and ensure alveolar stability during respiratory motion ().The clinical importance of surfactant in maintaining lung homeostasis is evident from the significant.
Pulmonary fibrosis (PF) is a chronic progressive lung disease caused by lung scarring. When the scar forms, the lung tissue becomes thicker and losses its ability to transfer oxygen into the bloodstream. The severity and natural course of pulmonary fibrosis varies from person to person.
Symptoms of pulmonary fibrosis include shortness of breath, dry cough, weight loss and fatigue. This signs and symptoms information for Surfactant Metabolism Dysfunction, Pulmonary, 4 has been gathered from various sources, may not be fully accurate, and may not be the full list of Surfactant Metabolism Dysfunction, Pulmonary, 4 signs or Surfactant Metabolism Dysfunction, Pulmonary, 4 .Endogenous pulmonary surfactant metabolism is not affected by mode of ventilation in premature infants with respiratory distress syndrome Assaad Merchak, Daphne J.
Janssen, Kajsa Bohlin, Bruce W. Patterson, Luc J. Zimmermann, Virgilio P. Carnielli, Aaron Hamvas *. For a general phenotypic description and a discussion of genetic heterogeneity of congenital pulmonary surfactant metabolism dysfunction, see SMDP1 ().
Clinical Features Martinez-Moczygemba et al. () reported a 4-year-old female with symptoms associated with Turner syndrome and respiratory insufficiency who had been diagnosed with PAP.